CAS No.: | 154-17-6 |
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Formula: | C6h12o5 |
EINECS: | 205-823-0 |
Acid-Base Property: | Alkaline Surface Disposal Agent |
Certification: | WQA |
Environmental Protection: | Yes |
Customization: |
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Common Name | 2-Deoxy-D-glucose | ||
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CAS Number | 154-17-6 | Molecular Weight | 164.156 |
Density | 1.4±0.1 g/cm3 | Boiling Point | 456.7±45.0 °C at 760 mmHg |
Molecular Formula | C6H12O5 | Melting Point | 146-147ºC |
MSDS | ChineseUSA | Flash Point | 244.1±25.2 °C |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 456.7±45.0 °C at 760 mmHg |
Melting Point | 146-147ºC |
Molecular Formula | C6H12O5 |
Molecular Weight | 164.156 |
Flash Point | 244.1±25.2 °C |
Exact Mass | 164.068466 |
PSA | 97.99000 |
LogP | -3.07 |
Vapour Pressure | 0.0±2.5 mmHg at 25°C |
Index of Refraction | 1.534 |
Storage condition | 2~8ºC |
2-Deoxy-D-glucose (2-DG) is a glucose analog that lacks the hydroxyl group at the 2-position of the glucose molecule. It is soluble in water. Structurally, it closely resembles glucose but lacks the hydroxyl group at the 2-position.
Glucose Analog: 2-Deoxy-D-glucose is structurally similar to glucose and can enter cells via glucose transporters. However, due to the absence of the hydroxyl group at the 2-position, it cannot undergo further metabolism in the glycolytic pathway and becomes trapped within the cell.
Glycolysis Inhibitor: 2-Deoxy-D-glucose acts as a competitive inhibitor of glucose metabolism. It is phosphorylated by hexokinase to form 2-deoxyglucose-6-phosphate but cannot be further metabolized by downstream enzymes. This leads to the inhibition of glycolysis, the primary pathway for glucose breakdown and energy production in cells.
Medical Applications: 2-Deoxy-D-glucose has been investigated for its potential therapeutic applications in various fields, including cancer research, neurodegenerative diseases, metabolic disorders, and viral infections. It has shown promising results in preclinical studies and is currently being evaluated in clinical trials.
Cancer Research: Cancer cells often exhibit increased glucose metabolism compared to normal cells. 2-Deoxy-D-glucose selectively targets cancer cells by disrupting their energy metabolism, leading to reduced cell proliferation and increased cell death. It is being studied as a potential adjuvant therapy in combination with other cancer treatments.
Neurodegenerative Diseases: Abnormal glucose metabolism and energy deficits are observed in several neurodegenerative diseases. 2-Deoxy-D-glucose has shown neuroprotective effects in preclinical models of Alzheimer's disease, Parkinson's disease, and Huntington's disease. It is being explored as a potential therapeutic strategy for these conditions.
Metabolic Disorders: Given its ability to inhibit glucose metabolism, 2-Deoxy-D-glucose has been investigated as a potential treatment for metabolic disorders such as diabetes and obesity. It may help regulate glucose homeostasis and improve insuli sensitivity.
Viral Infections: Some viruses rely on glucose metabolism for their replication and survival. 2-Deoxy-D-glucose has demonstrated antiviral activity against certain viruses by inhibiting viral glycolysis and interfering with viral replication.
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