CAS No.: | 50-01-1 |
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Formula: | CH6cln3 |
EINECS: | 200-002-3 |
Classification: | Biochemical Reagents |
Grade: | AR |
Specific Usage: | For Biological Purpose, Technical Grade |
Customization: |
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Guanidine hydrochloride is an organic substance with the chemical formula CH6ClN3 and is a white or yellowish lump. Used as an intermediate in medicine, pesticides, dyes and other organic compounds, it is an important raw material for the manufacture of sulfonamides and folic acid, and can also be used as an antistatic agent for synthetic fibers.
Use
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase
Product Name | Guanidine hydrochloride |
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Cas | 50-01-1 |
Density | 1.18 g/mL at 25 °C(lit.) |
Boiling Point | 132.9ºC at 760 mmHg |
Melting Point | 180-185 °C(lit.) |
Molecular Formula | CH6ClN3 |
Molecular Weight | 95.531 |
Exact Mass | 95.025024 |
PSA | 75.89000 |
LogP | 1.14090 |
Index of Refraction | n20/D 1.465 |
Storage condition | Store at RT. |
Stability | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
Water Solubility | 2280 g/L (20 ºC) |
Packaging storage and transportation
1. Packing: 25 kg/bag
2. Storage: Keep the storage unit sealed, stored in a cool, dry place, and ensure that the work room has good ventilation or exhaust.
3. Transportation: This product is non-toxic and harmless, non-flammable and explosive dangerous goods. It can be transported by car, sea or train. Less carload, vehicle is not limited, agent consignment.
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